Palmitoylation-dependent Estrogen Receptor Membrane Localization: Regulation by 17 -Estradiol
نویسندگان
چکیده
*Department of Biology, University Roma Tre, I-00146 Rome, Italy; †Interdepartmental Laboratory for Electron Microscopy, University Roma Tre, I-00146 Rome, Italy; ‡National Institute for Infectious Diseases Istituto di Ricovero e Cura a Carattere Scientifico Lazzaro Spallanzani, I-00149 Rome, Italy; §Department of Chemistry, Chemical Engineering, and Materials, University of L’Aquila, I-67100 L’Aquila, Italy; and Department of Experimental Biology, University of Bologna, I-40126 Bologna, Italy
منابع مشابه
Palmitoylation of estrogen receptors is essential for neuronal membrane signaling.
In addition to activating nuclear estrogen receptor signaling, 17β-estradiol can also regulate neuronal function via surface membrane receptors. In various brain regions, these actions are mediated by the direct association of estrogen receptors (ERs) activating metabotropic glutamate receptors (mGluRs). These ER/mGluR signaling partners are organized into discrete functional microdomains via c...
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Estrogen receptor alpha (ERα) activation functions AF-1 and AF-2 classically mediate gene transcription in response to estradiol (E2). A fraction of ERα is targeted to plasma membrane and elicits membrane-initiated steroid signaling (MISS), but the physiological roles of MISS in vivo are poorly understood. We therefore generated a mouse with a point mutation of the palmitoylation site of ERα (C...
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